Gen Catabolism in Renal Disease

Royal Victoria Infirmary. Newcastle upon Tyne Radio-fibrinogen catabolism study is a sensitive way of assessing active participation of fibrin in the pathogenesis of renal disease. In general in oliguric patients accelerated fibrinogen catabolic rates are reflected by an increase of serum fibrin products. To evaluate further the role of intravascular coagulation and to assess the potential of heparinization in management, patients with oliguric glomerulonephritis, accelerated hypertension and transplant rejection underwent short-term administration of heparin during the course of a radio-fibrinogen study. Heparin produced an increase of glomerular filtration rate measured by Cr-EDTA clearances. Beneficial effects on fibrinogen catabolism were also found in some cases of accelerated hypertension and transplant rejection, but heparin alone did not influence rapidly progressive glomerulonephritis. 1. EFFECT O F HEPARIN ON RADIO FIBRINO-